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Folate Metabolic Pathway Single Nucleotide Polymorphisms: A Predictive Pharmacogenetic Marker of Methotrexate Responsel in Indian (Asian) Patients with Rheumatoid Arthritis

Year: 2015
Type: article
Study design: Observational Study
Abstract: AIM: We evaluated the pharmacogenetic influence of genetic polymorphisms in folate pathway genes in Indian rheumatoid arthritis patients receiving methotrexate (MTX). PATIENTS & METHODS: Twelve polymorphisms within nine folate pathway genes were analyzed for association with MTX response in 322 Indian rheumatoid arthritis (RA) patients and MTX pharmacokinetics in 94 RA patients. RESULTS: Polymorphisms in GGH, SHMT1 and TS were associated with MTX-related adverse events while SNPs in MTHFR and RFC1/SLC19A1 were associated with MTX efficacy. TS5'UTR and SHMT1 polymorphisms were associated with higher plasma levels of MTX. CONCLUSION: Polymorphisms in folate-MTX pathway genes contribute to MTX response and affect MTX concentrations in Indian RA patients. A toxicogenetic index could identify patients who develop adverse events to MTX.
DOI: 10.2217/pgs.15.145
Authors: Yogita Ghodke-Puranik, Amrutesh S Puranik, Pooja Shintre, Kalpana Joshi, Bhushan Patwardhan, Jatinder Lamba, Timothy B Niewold, Arvind Chopra
Language: English
Subfield: Pharmacology
Open Access status: green
Funders: Rheumatology Research Foundation, Cure JM Foundation, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awards: The Role of IL-17 Axis in Inflammatory Myositis, Interferon Alpha as a Tool for Gene Discovery in Human Lupus, G2288505403, G2382605511, Interferon Regulatory Factor 5 in Human Lupus Pathogenesis, G3209343207, G462048303, G499069531, G6254433419, G6620899976, G9000019930, Genomics of AML Prognosis
OpenAlex ID: W2184889105
FWCI: 9.297
Cites: 47
Cited by: 58
Related to: 10