Work

One-Pot Synthesis of 2-Imidazolines via the Ring Expansion of Imidoyl Chlorides with Aziridines

Year: 2011

Type: article

Abstract: We herein report a simple and convenient one-pot synthesis of highly substituted 2-imidazolines in a regiocontrolled and stereospecific matter through the ring expansion reaction of an imidoyl chloride with an aziridine, analogous to the Heine reaction.

Source: The Journal of Organic Chemistry

DOI: 10.1021/jo200101q

Authors: Michael R. Kuszpit, William D. Wulff, Jetze J. Tepe

Institution: Michigan State University

Language: English

Topic: Synthesis and Reactions of Organic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Cancer Institute

Awards: G2087089305, Inhibition of interleukin-6 production for the treatment of multiple myeloma