Work

Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics

Year: 2012

Type: review

Abstract: Down syndrome is a complex disease that has challenged molecular and cellular research for more than 50 years. Understanding the molecular bases of morphological, cellular, and functional alterations resulting from the presence of an additional complete chromosome 21 would aid in targeting specific genes and pathways for rescuing some phenotypes. Recently, progress has been made by characterization of brain alterations in mouse models of Down syndrome. This review will highlight the main molecular and cellular findings recently described for these models, particularly with respect to their relationship to Down syndrome phenotypes.

Source: Neural Plasticity

DOI: 10.1155/2012/171639

Author: Nicole Créau

Institutions: Centre National de la Recherche Scientifique, Sorbonne Paris Cité, Unit of Functional and Adaptive Biology, Université Paris Diderot

Language: English

Topic: Down syndrome and intellectual disability research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,830