Ultrastructural Arguments for the Extracellular Location of Amyloid Deposits
Year: 2015
Type: article
Abstract: Objectives: Amyloidosis is a disease characterized by the occurrence of small and large deposits containing a fibrillar material of insoluble proteins, which is lately more and more frequently identified due also to electron microscopy. The pathogeny and mechanisms of amyloidosis have still many question marks. Most people consider the amyloid deposits as interstitial accumulations. Some authors are still considering formation of amyloid collections both intra and extracellular. Methods: To assume a definite opinion in this matter we have investigated carefully with the electron microscope, the occurrence of amyloid fibrillar material in atrial cardiomyocytes in cases of isolated atrial amyloidosis, and in the glomeruli in renal amyloidosis.
Authors: E Mandache, Mircea Penescu, Carol Davila
Language: English
Subfield: Internal Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2184955044