Work

Effects of Flavonoid Fractions from Calendula officinalis Flowers in Parent and Tamoxifen Resistant T47D Human Breast Cancer Cells

Year: 2005

Type: article

Abstract: Three major flavonoid fractions were separated from a methanol extract of Calendula officinalis flowers by preparative TLC. These fractions were evaluated for the inhibition of parent and tamoxifen resistant T47D human breast cancer cells. We also examined the effect of quercetin and isorhamnetin on the growth of parent and resistant T47D cells in the presence and absence of tamoxifen. It was foundthat quercetin increased cell proliferation of the resistant T47D cells at the presence of tamoxifen but no effect was detected by using quercitin alone. The fractions isolated from Calendula officinalis did not show any inhibitory effects on the cells.Isorhamnetin did not have any proliferative or anti-proliferative activity on the both cell lines.

Source: Iranian journal of pharmaceutical sciences

DOI: 10.22037/ijps.v1.39492

Authors: Seyed Nasser Ostad, H R Monsef Esfahani, Seyed Kazem Taheri, E Azizi, Faramarzi

Institutions: University of Tehran, Tehran University of Medical Sciences

Language: English

Topic: Flavonoids in Medical Research

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Tehran University of Medical Sciences and Health Services