A Personalized Medicine Approach for Asian Americans with the Aldehyde Dehydrogenase 2*2 Variant
Year: 2014
Type: review
Abstract: Asian Americans are one of the fastest-growing populations in the United States. A relatively large subset of this population carries a unique loss-of-function point mutation in aldehyde dehydrogenase 2 (ALDH2), ALDH2*2. Found in approximately 560 million people of East Asian descent, ALDH2*2 reduces enzymatic activity by approximately 60% to 80% in heterozygotes. Furthermore, this variant is associated with a higher risk for several diseases affecting many organ systems, including a particularly high incidence relative to the general population of esophageal cancer, myocardial infarction, and osteoporosis. In this review, we discuss the pathophysiology associated with the ALDH2*2 variant, describe why this variant needs to be considered when selecting drug treatments, and suggest a personalized medicine approach for Asian American carriers of this variant. We also discuss future clinical and translational perspectives regarding ALDH2*2 research.
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
Awards: G3846759050, G5111541616, Mechanisms of Ethanol-Induced Cardiac Protection, Role of the TRPV1 channel in myocardial salvage from ischemia-reperfusion injury, Role of the TRPV1 channel in myocardial salvage from ischemia-reperfusion injury, Ethanol and aldehyde dehydrogenases in health and disease
OpenAlex ID: W2111329816