Year: 2014
Type: article
Abstract: Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.
Authors: A Alfirevic, D Neely, J Armitage, H Chinoy, R G Cooper, R Laaksonen, D F Carr, K M Bloch, J Fahy, A Hanson, Q-Y Yue, M Wadelius, A H Maitland-van Der Zee, D Voora, B M Psaty, C N A Palmer, M Pirmohamed
Institutions: University of Liverpool, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne Hospital, University of Oxford, University of Manchester, Zora Biosciences (Finland), Medical Products Agency, Uppsala University, Science for Life Laboratory, Utrecht University, Duke University, Group Health Cooperative, Kaiser Permanente Washington Health Research Institute, University of Washington, Ninewells Hospital
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,410
Awards: Centre for Drug Safety Science (CDSS), NIHR Senior Investigator Award, Personalisation of tREatment In Cardiovascular disease through next generation sequencing in Adverse Drug Reactions, Pharmacogenetics of statin-induced muscle toxicity: exploration using the UK General Practice Research Database (G, G6555362311, G8641640586
OpenAlex ID: W2035681453