Work

SecA: A Potential Antimicrobial Target

Year: 2015

Type: review

Abstract: There is a consensus in the medical profession of the pressing need for novel antimicrobial agents due to issues related to drug resistance. In practice, solutions to this problem to a large degree lie with the identification of new and vital targets in bacteria and subsequently designing their inhibitors. We consider SecA a very promising antimicrobial target. In this review, we compile and analyze information available on SecA to show that inhibition of SecA has a multitude of consequences. Furthermore, we discuss issues critical to the design and evaluation of SecA inhibitors.

Source: Future Medicinal Chemistry

DOI: 10.4155/fmc.15.42

Authors: Arpana S Chaudhary, Weixuan Chen, Jinshan Jin, Phang C Tai, Binghe Wang

Institution: Georgia State University

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases