Year: 2014
Type: article
Study design: Observational Study
Abstract: Background: An association between increased OPN levels and lowered bone mineral density (BMD) withincreased bone turnover markers was established. The aim of this study is to evaluate the levels of OPN in OPpatients who receive antiresorptive treatment (ART).Methods: Ninety female OPpatients in the post-menopausal period for at least a year in the age range of 45 -70 years and 80 healthy female volunteers were included in the study. OP patients were divided into 2subgroups as ART-receiving (60 patients; bisphosphonate (15), calcitonin (15), raloxifene (15), strontiumranelate (15) and ART non-receiving (30 patients). Bone mineral density was analyzed using the dual energyX-ray absorptiometry method. The plasma OPN concentration was calculated using the enzyme-linkimmunosorbent assay method.Results: OPN levels were significantly lower in antiresorptive-receiving OP patients compared to OPpatients who did not receive ART and compared to the control group (p<0.001 and p=0.008 respectively).There was no meaningful difference in terms of the OPN values between the controls and OP patients whodid not receive ART(p>0.05).Conclusions: Lowered OPN levels in ART-receiving OP patients suggest that OPN could be used as abiomarker in ARTfollow-up in OP.
Source: DergiPark (Istanbul University)
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2186469612