Comparison between the effects of typical and atypical antipsychotics on oxidative stress status in schizophrenic patients
Year: 2010
Type: article
Study design: Observational Study
Abstract: We determined the specific activities of some enzymatic antioxidant defenses like superoxide dismutase\n(SOD) and glutathione peroxidase (GPX), as well as a lipid peroxidation marker (MDA-malondialdehyde) from the\nserum of patients with schizophrenia treated with typical and atypical antipsychotics, in comparison with a normal age-\nmatched control group. We observed an increased oxidative stress in schizophrenic patients treated with typical\nantipsychotics, compared to controls. Moreover, we demonstrated an antioxidant effect of atypical antipsychotics, since\nthese patients showed an increased activity of SOD, compared to control subjects and a slightly decrease of MDA
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2186685734