Local Allergic Reaction to Ocular Chloramphenicol Ointment: A Diagnosis by High Index of Clinical Suspicion
Year: 2014
Type: article
Study design: Case Report
Abstract: Chloramphenicol is a widely used topical ointment applied routinely for ocular and periorbital infections due to its wide spectrum of anti-bacterial activity.Local delayed hypersensitivity reaction to chloramphenicol is a well reported but uncommon adverse effect, and has been reported to mismanaged initially as an infective cellulitis.The confirmatory tests for drug allergy are often not possible in developing countries and hence, the diagnosis is usually made with high index of clinical suspicion.Hereby, we are reporting a case of local hypersensitivity reaction to chloramphenicol after ocular use for adenexal infection, which was diagnosed with high index of suspicion without any diagnostic test, and was managed timely and successfully.advised oral ciprofloxacin 500mg twice a day and ofloxacin ointment locally for 5 days, which responded well. DiscussionTopical ocular chloramphenicol is relatively inexpensive and have broad-spectrum coverage of most gram-positive, gram-negative, and anaerobic bacteria [2].The topical ocular form of chloramphenicol became available in 1948, and since then it has become the most popular antibiotic prescribed topically by general practitioners for all red eyes and periocular infections [3,4].In a study chloramphenicol was found as the most commonly prescribed treatment by general
Author: R Ranjan
Institution: KG Hospital
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2187211425