Work

The role of the cytoskeleton and molecular motors in endosomal dynamics

Year: 2014

Type: review

Abstract: The endocytic pathway is essential for processes that define how cells interact with their environment, including receptor signalling, cell adhesion and migration, pathogen entry, membrane protein turnover and nutrient uptake. The spatial organisation of endocytic trafficking requires motor proteins that tether membranes or transport them along the actin and microtubule cytoskeletons. Microtubules, actin filaments and motor proteins also provide force to deform and assist in the scission of membranes, thereby facilitating endosomal sorting and the generation of transport intermediates.

Source: Seminars in Cell and Developmental Biology

DOI: 10.1016/j.semcdb.2014.04.011

Authors: Elizabeth Granger, Gavin McNee, Victoria Allan, Philip Woodman

Institution: University of Manchester

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,670

Funders: Wellcome Trust, Directorate for Biological Sciences, Medical Research Council, Biotechnology and Biological Sciences Research Council