Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ Induced Epileptic Seizures. Journal of Applied Biological Sciences
Year: 2007
Type: article
Abstract: The aim of this work was to evaluate hippocampal neurons in the rat brain after single and repetetive seizures induced bypentyleneterazol (PTZ) administration at light- and electron-microscopically. Acute- and chronic-PTZ groups of male Wistaralbino rats were given PTZ intraperitoneal injection (i.p.), and the age-matched rats in control group were injected with normalsaline. We determined contributions of apoptosis and necrosis to neuronal damage in Nissl-stained- and ultrathin-sections. Necroticneurons were observed in PTZ-treated groups, especially in the chronic-PTZ group. Histological changes were perikaryal swelling,chromatolysis and decreasing of Nissl in the necrotic neurons. Necrotic and apoptotic neurons of the hippocampus were observedultrastructurally in the PTZ groups. These findings demonstrated a significant decrease in the number of hippocampal neurons inthe chronic-PTZ group. It is clear that in the hippocampal regions repeated PTZ-induced seizures of the rats cause neuronal damageand neuronal loss.
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: Kocaeli Üniversitesi
OpenAlex ID: W2188178600