Work

Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2.

Year: 2005

Type: article

Abstract: Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of mPGES-1 in the increased local production of PGE2 observed in inflammatory arthritis. The focus of this article is to review some recent advances in our understanding of mechanisms specific to the regulation of inducible mPGES-1 in inflammatory arthritis.

Source: Arthritis Research

DOI: 10.1186/ar1748

Authors: Annaleise V Sampey, Seetha Monrad, Leslie J Crofford

Institutions: University of Michigan, University of Kentucky

Language: English

Topic: Inflammatory mediators and NSAID effects

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W1819165858

FWCI: 3.409

Cites: 30

Cited by: 85

Related to: 10