Year: 2006
Type: article
Study design: Case Report
Abstract: Presentation W.E.W. is a 54-year-old white man who has type 1A diabetes, the most common form of type 1 diabetes.Type 1A diabetes is a cellular-mediated autoimmune disease characterized by the production of autoantibodies causing cell destruction and subsequent insulin deficiency. 1 At age 12 years, he was diagnosed with vitiligo.This autoimmune dermatological process involved mainly his neck, arms, and hands.After repeated medical consultations, he and his family received reassurance, but no treatment was recommended.At age 14 years, W.E.W. was diagnosed with type 1 diabetes after the onset of polyuria, polydipsia, and weight loss.Because an older brother had been previously diagnosed at age 12 years with type 1 diabetes, his mother diagnosed his diabetes via home urine testing in 1964.Type 1 diabetes was subsequently confirmed via venous blood testing, W.E.W. was hospitalized, and insulin therapy was initiated.In 1984, W.E.W. was diagnosed with Hashimoto's thyroiditis after experiencing fatigue, poor exercise tolerance, and weight gain.Thyroid peroxidase antibodies were positive, and he was begun on levothyroxine replacement therapy.His presenting symptoms resolved with this treatment.At age 34 years, W.E.W. now had three coexisting autoimmune diseases.Pertinent family history includes: • mother with Hashimoto's thyroiditis • brother with type 1 diabetes • paternal grandfather with Graves' disease
Source: Clinical Diabetes
Authors: Russell D. White, George D. Harris
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2021763843