EFFECTS OF a -LIPOIC ACID SUPPLEMENTATION ON ENDURANCE CAPACITY AND ENERGY METABOLISM IN RATS
Year: 2008
Type: article
Abstract: α‐Lipoic acid (ALA) functions as a cofactor of mitochondrial enzymes, is closely related with mechanism of aerobic energy production. Therefore, ALA is expected to provide to improvement of endurance capacity and recovery of fatigue, but it is not well known that ALA has effect of energy metabolism. In this study, we investigated the promoting effects of ALA on energy metabolism in rats, used exercise time to exhaustion in loading swimming test and energy expenditure before and after exercise as indicators. Male Wistar rats were orally administrated 100mg/kg body weight of ALA for 4 weeks. The effects of ALA on exhaustion time were not observed, while resting metabolic rate was significantly increased by daily administration of ALA. Moreover, ALA increased total energy expenditure of the post‐exercise, but the difference was not significant. These results suggest that ALA does not enhance endurance, but promotes activation of energy metabolism.
Authors: Tatsuhiro Matsuo, Kanako Yagi
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2188704946