Seroprevalence of Hepatitis B Surface Antigen (HBsAg) Co-infections among HIV Positive Individuals. .
Year: 2014
Type: article
Study design: Observational Study
Abstract: Confection with Hepatitis B virus (HBV) and HIV is common, with 70-90% of HIV-infected individuals in the United States having evidence of past or active infection with HBV.However, in Asia and sub-Saharan Africa, where vertical and early childhood exposure are the most common modes of transmission, respectively.Therefore, the prevalence of HBV among HIV-infected individuals is higher at an estimated 20-30%.One hundred and eightyeight (188) HIV confirmed subjects on Highly Active Anti-retroviral Therapy (HAART), attending General Hospital Pankshin, Plateau state Nigeria, were enrolled for the study.Consent of the volunteers was sought after which a well-structured questionnaire was issued to volunteers to obtain social and demographic data.Overall result showed that, sixty-six 66(35%) were positive for the hepatitis B surface antigen (HBsAg).Gender distributions showed that 18(9.6) were males compared to 48 (25.5%) females.The mean value for CD4+ cell absolute count and values of alanine transaminase value for HBsAg positive subjects were determined with values ranging between 211-361 cells/µl and 25.0-27.3I.u respectively, this is in contrast to the CD4+cell absolute count, and alanine transaminase values for HBsAg negative subjects whose values ranged from 181-472 cells/µl and 14.3-28.3I.u respectively.Similarly, the CD4+ count of HIV/HBV co-infected subjects, who were noted to respond to HAART recorded a better outcome.It is therefore needful that all HIV positive patients be screened for HBsAg, while patients who lack the HBsAb and do not have the HBsAg positivity or occult HBV should be vaccinated against HBV so as to influence the clinical management of subjects on HARRT.[Edith A.Onwuliri, James A.Ndako and Moses Y. Dimlong.Seroprevalence of Hepatitis B Surface Antigen [HBsAg] Co-infections among HIV Positive Individuals.
Authors: Edith A. Onwuliri, Moses Y. Dimlong
Language: English
Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2188919871