The Role of the Renin-Angiotensin System in Amyloid Metabolism of Alzheimer's Disease.
Year: 2014
Type: article
Abstract: UNLABELLED: The etiology of Alzheimer's disease (AD) remains unclear. Epidemiologic studies suggest hypertension plays a contributing role to AD. Recently, several experimental and observational studies showed interaction between the renin-angiotensin system and amyloid-β, a key pathologic feature of AD, with diverse results. This article reviews molecular, genetic, experimental and clinical data to clarify the impact on an AD patient with angiotensin converting enzyme inhibitor and angiotensin II receptor blocker therapy, with some guidance for the direction of possible future research. KEY WORDS: Alzheimer's disease; Amyloid-β; Renin angiotensin system.
Source: Europe PMC (PubMed Central)
Authors: Chao-Liang Chou, Hung-I Yeh
Institutions: Mackay Memorial Hospital, Mackay Medical University
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2188931040