Inhibitors of Microtubule Assembly Produced by the Marine Fungus Strain TUF 98F139 Collected in Palau
Year: 2002
Type: article
Abstract: A mixture of four fatty acids, oleic acid, linoleic acid, stearic acid, and palmitic acid, was isolated as the inhibitor of microtubule assembly from mycelia of the marine fungus strain TUF 98F139, which was isolated from a marine sponge collected at Palau in 1998. The mixture, which gave a single spot on TLC, showed the inhibitory activity of 57% at 50 ppm. The bioassay with authentic specimens of fatty acids revealed that unsaturated fatty acids, oleic acid and linoleic acid, were active (52 and 58% at 50 ppm, respectively). It is the first time to report that unsaturated fatty acids inhibit microtubule assembly.
Authors: Michio Namikoshi, Shigeo Suzuki, Shiori Meguro, Hisayoshi Kobayashi, Yuji Mine, Isao Kasuga
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2188966523