Work

Synaptic Properties of Connections between the Primary and Secondary Auditory Cortices in Mice

Year: 2011

Type: article

Abstract: Little is known regarding the synaptic properties of corticocortical connections from one cortical area to another. To expand on this knowledge, we assessed the synaptic properties of excitatory projections from the primary to secondary auditory cortex and vice versa. We identified 2 types of postsynaptic responses. The first class of responses have larger initial excitatory postsynaptic potentials (EPSPs), exhibit paired-pulse depression, are limited to ionotropic glutamate receptor activation, and have larger synaptic terminals; the second has smaller initial EPSPs, paired-pulse facilitation, metabotropic glutamate receptor activation, and smaller synaptic terminals. These responses are similar to the driver and modulator properties previously identified for thalamic and thalamocortical circuitry, suggesting that the same classification may extend to corticocortical inputs and have an implication for the functional organization of corticocortical circuits.

Source: Cerebral Cortex

DOI: 10.1093/cercor/bhr029

Authors: E. N. Covic, S. M. Sherman

Institution: University of Chicago

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funder: National Institute on Deafness and Other Communication Disorders

Award: Information processing in sensory systems