Year: 2014
Type: article
Abstract: Obstructive sleep apnea syndrome (OSAS) is a prevalent disorder that has beenreported to occur in 2 to 4% of middle-aged adults. A similar prevalence of OSAS hasbeen reported from India as well. However, this condition is frequently unrecognizedand underdiagnosed. Important pathophysiological changes in patients withobstructive sleep apnea (OSA) is an alteration in human upper airway leading to areduction in cross-sectional area of the upper airway contributing to the easycollapsibility of upper airway during sleep. Other pathophysiological changes in OSAare oxidative stress, systemic inflammation, sympathetic nerve activation, endothelialdysfunction, procoagulant activity, intrathoracic pressure changes and metabolicdysregulation. The gold standard for diagnosis of OSA is full polysomnography.Key words: Obstructive sleep apnea, Central sleep apnea, Oxidative stress,Metabolic dysregulation, Polysomnography
Author: V K Vijayan
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2188991128