Fluoxetine plus cognitive behavioural therapy was most effective for adolescents with major depressive disorder March J, Silva S, Petrycki S, et al. Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents with Depression Study (TADS) randomized controlled trial. JAMA 2004;292:807-20. Clinical impact ratings GP/FP/Primary care wwwwwwq Mental health wwwwwwq Psychiatry wwwwwwq Paediatrics