Antibiotic resistance patterns of Escherichia coli isolated from HIV-sero positive adults at Mbagathi District Hospital, Nairobi, Kenya.
Year: 2010
Type: article
Abstract: Objectives: To determine changes in antibiotic resistance patterns in E. coli from persons living with \nHIV/AIDS (PLWHA). Methodology and results: A total of 264 strains of E. coli were isolated from PLWHA. \nThe isolates were tested for antimicrobial susceptibility by Kirby Bauer disk diffusion technique. Out of the \n216 (81.81%) E.coli from PLWHA and taking antibiotics (HIV+A+), 209-(96.76%), 198-(91.67%) and 188- \n(87.04%) isolates were resistant to trimethoprim-sulphamethazole, tetracycline and ampicillin respectively. \nAll isolates from PLWHA not taking antibiotics(HIV+A-) were sensitive to fluoroquinolones and nalidixic acid \nbut thirty nine (83.33%) of the them were resistant to trimethoprim-sulphamethazole.The most prevalent \nresistance was to trimethoprim-sulphamethazole and ampicillin. \nConclusion and application of findings: prolonged exposure to antibiotic makes PLWHA harbour strains of \nE. coli that are significantly more resistant to antibiotics with varying resistance patterns. The findings of \nthis study should have major implications on public health policy guidelines on managing antimicrobial \nresistance in PLWHA, antimicrobial resistance detection modules and intervention schemes. It can also \nhelp in planning regular monitoring of antibiotic resistance patterns in order to provide the basis for \ndeveloping rational prescription guidelines. \nKey words: Acquired immunodeficiency syndrome, opportunistic infections, antibiotics, Escherichia coli, \nresistance
Language: English
Subfield: Microbiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2189139784