Year: 2007
Type: article
Abstract: The multitude and abundance of macrophage-derived mediators in rheumatoid arthritis and their paracrine/autocrine effects identify macrophages as local and systemic amplifiers of disease. Although uncovering the etiology of rheumatoid arthritis remains the ultimate means to silence the pathogenetic process, efforts in understanding how activated macrophages influence disease have led to optimization strategies to selectively target macrophages by agents tailored to specific features of macrophage activation. This approach has two advantages: (a) striking the cell population that mediates/amplifies most of the irreversible tissue destruction and (b) sparing other cells that have no (or only marginal) effects on joint damage.
Source: Arthritis Research & Therapy
DOI: 10.1186/ar2333
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,690
Awards: Verbesserung der Leistungsfähigkeit der klinischen Forschung durch Förderung von 4 Forschungsschwerpunkten der Medizinischen Fakultät, Verbundprojekt: Nationales Genomforschungsnetz 2 - Genomnetz Infektion: Von der pathogen-induzierten Signatur zu therapeutischen Zielgenen: Vergleichende und funktionelle Analyse der Entzündungsreaktion bei Gesunden und Erkrankten, Teilbereich chronische Entzündung, G4008604033
OpenAlex ID: W2081829590