Work

IL-15 Agonists: The Cancer Cure Cytokine

Year: 2013

Type: article

Abstract: memory CD8 T cells. The bioactivity of IL-15 in vivo is conferred mainly through a trans-presentation mechanism in which IL-15 is presented in complex with the α-subunit of soluble IL-15 receptor (IL-15R) to NK, NKT or T cells rather than directly interacts with membrane-bound IL-15R. With these understandings, recent studies have been focused on generating IL-15 agonists which consist of IL-15 and partial or whole of soluble IL-15R to improve its in vivo bioactivity. This minireview will summarize the key features of IL-15 as a potential cancer treatment cytokine and the most recent development of IL-15 agonists and preclinical studies. Critical milestones to translate the pre-clinical development to in-patients treatment are emphasized.

Source: Journal of Molecular and Genetic Medicine

DOI: 10.4172/1747-0862.1000085

Author: Jennifer Wu

Institutions: Medical University of South Carolina, University of Washington, MUSC Hollings Cancer Center

Language: English

Topic: Cytokine Signaling Pathways and Interactions

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: China Scholarship Council, National Cancer Institute