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Osteonecrosis of the jaws associated with the use of zoledronic acid in multiple myeloma patients

Year: 2006

Type: article

Abstract: Osteonecrosis of the jaws has recently been identified as a complication in patients treated with bisphosphonates.We report two case-reports of patients with multiple myeloma treated with zoledronic acid who had developed osteonecrosis of the mandible.The duration of treatment with zoledronic acid was 13 months in each case, with a cumulative zoledronic acid dose of 72 mg in one case and 144 mg in the other.The lesions were resistant to conservative debridement, surgery and antibiotic therapy.Clinicians should be aware of this potential serious complication i.e. bone necrosis in multiple myeloma patients receiving long-term treatment with potent bisphosphonates.It is recommended to perform dental examination to identify and treat all predisposing conditions before bisphosphonate treatment is started.

Source: Via Medica Journals

Authors: M Kraj, Ryszard Pogłód, S Maj, Ewa Mendek‐Czajkowska, Katarzyna Owczarska

Language: English

Topic: Bone health and treatments

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2189375897

FWCI:

Cites: 22

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Related to: 10