MicroRNAs in Experimental Models of Movement Disorders
Year: 2011
Type: review
Abstract: MicroRNAs (miRNAs) are small RNAs comprised of 20-25 nucleotides that regulates gene expression by inducing translational repression or degradation of target mRNA. The importance of miRNAs as a mediator of disease pathogenesis and therapeutic targets is rapidly emerging in neuroscience, as well as oncology, immunology, and cardiovascular diseases. In Parkinson's disease and related disorders, multiple studies have identified the implications of specific miRNAs and the polymorphisms of miRNA target genes during the disease pathogenesis. With a focus on Parkinson's disease, spinocerebellar ataxia, hereditary spastic paraplegia, and Huntington's disease, this review summarizes and interprets the observations, and proposes future research topics in this field.
Source: Journal of Movement Disorders
DOI: 10.14802/jmd.11011
Authors: Soon-Tae Lee, Manho Kim
Institutions: Seoul National University, Seoul National University Hospital
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2049903093