The modulation of inflammatory response in the peritoneal cavity through stimulation of the pleural cavity: an experimental study in the rat.
Year: 1980
Type: article
Abstract: To establish whether local inhibition of emigration or a centrally acting mechanism is responsible for the diminished response to a second inflammatory stimulus, three groups of young adult male Sprague-Dawley rats received in intrapleural injections of glycogen followed 4 h later by intra-peritoneal Beef Heart Infusion/protease Peptone. Two, 4 and 8 h after the second injection cell counts were made on both the pleural and peritoneal effusions. Circulating PMNs were also monitored using tail vein blood. The prior injection of glycogen intrapleurally significantly suppressed the subsequent accumulation of peritoneal PMNs in response to the second stimulus. The mechanism of this suppression is discussed.
Source: PubMed Central
Authors: W H Lu, D M Williams
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2189837431