Work

RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines

Year: 2015

Type: article

Source: Oncogene

DOI: 10.1038/onc.2015.431

Authors: O Ksionda, A A Melton, J Bache, M Tenhagen, J Bakker, R Harvey, S S Winter, I Rubio, J P Roose

Institutions: University of California, San Francisco, Jena University Hospital, Friedrich Schiller University Jena, University of New Mexico, Center for Sepsis Control and Care

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences

Awards: G1504112592, G1560114048, G1849608474, G2901481919, The MIT Center for Single-Cell Dynamics in Cancer (SCDC), G3609659413, Support for Human Specimen Banking in NCI-Sponsored Clinical Trials-(CGB), G421865639, G4219210399, Children's Oncology Group Statistics and Data Center, Molecular understanding of leukemic bone marrow cytokine-Ras signals and metabolic dependence, G5781986915, G77486010, University of New Mexico Cancer Center Support Grant, Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR, G997771125

OpenAlex ID: W2191633397

FWCI: 1.286

Cites: 39

Cited by: 40

Related to: 10