Year: 2015
Type: article
Abstract: IKZF1 ( Ikaros ) encodes a DNA-binding protein that acts as a master regulatory of hematopoiesis and a tumor suppressor in acute lymphoblastic leukemia (ALL). 1 , 2 , 3 , 4 The deletion and/or mutation of Ikaros is associated with the development of B-cell acute lymphoblastic leukemia (B-ALL) with poor outcome. 5 , 6 , 7 , 8 , 9 , 10 , 11 Ikaros directly associates with components of the histone deacetylase complex (NuRD), HDAC1, HDAC2 and Mi-2. 12 , 13 , 14 Although Ikaros is hypothesized to regulate the transcription of target genes by recruiting the NuRD complex, the mechanism of Ikaros-mediated transcriptional regulation in leukemia is still unknown. Here we use a systems biology approach to determine the mechanism through which Ikaros and HDAC1 regulate gene expression in human B-ALL.
Source: Leukemia
DOI: 10.1038/leu.2015.331
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,190
Funders: St. Baldrick's Foundation, Pennsylvania State University, Four Diamonds, Cancer Research UK, National Natural Science Foundation of China, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences, National Center for Research Resources, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities, Hyundai Hope On Wheels
Awards: Penn State Clinical and Translational Science Institute, Loma Linda University Center for Health Disparities Research, Statistical methods for improving reproducibility and utility of chromatin interaction data, Xenograft Model to Study Impact of CRLF2-Ligand in Hispanic Childhood B-ALL, Ikaros isoform 6在费城染色体阳性急性淋巴细胞白血病中染色质重塑的调控机制研究, The Role of Zinc Finger Genes in Leukemogenesis, G531917761, LLU-NIH Initiative for Maximizing Student Development, Penn State Clinical and Translational Science Institute, Central tolerance mechanisms in B-cell malignancies, Metabolic gatekeepers in B-cell malignancies, Penn State Clinical and Translational Science Institute
OpenAlex ID: W2194616187