Association of CCND1 gene polymorphism with cervical cancer susceptibility in Caucasian population: a meta-analysis.
Year: 2015
Type: article
Study designs: Systematic Review, Meta-Analysis
Abstract: OBJECTIVE: To study G870A polymorphism in CCND1 gene and the risk of cervical cancer susceptibility in Caucasian population by meta-analysis. METHODS: Search the correlative study of G870A polymorphism in CCND1 gene and cervical cancer susceptibility in PubMed and EMBASE database, and extract the reference data according to the including criteria. We used RevMan 5.2 software to merge the OR value and 95% confidence interval and to perform meta-analysis. RESULTS: Five case-control studies were enrolled into the analysis, including 1665 patients with cervical cancer and 2511 healthy people as control. It was revealed by meta-analysis that, in the Caucasian population, there was no significant correlation between G870A polymorphism in CCND1 gene and the risk of cervical cancer (G allele vs. A: OR = 1.01, 95% CI = 0.80-1.27, P = 0.95; AA vs. GA + GG: OR = 1.13, 95% CI = 0.98-1.30, P = 0.10; (GA + AA) vs. GG: OR = 1.15, 95% CI = 0.72-1.85, P = 0.55). CONCLUSION: G870A polymorphism in CCND1 gene may be uncorrelated with the development of cervical cancer in Caucasian population.
Source: Europe PMC (PubMed Central)
Authors: Mei Yang, Hongmei Zhu, Ting Hu, Shanling Liu, He Wang
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2195584672