Work

Fatty acyl incorporation in the biosynthesis of WAP-8294A, a group of potent anti-MRSA cyclic lipodepsipeptides

Year: 2015

Type: article

Abstract: evidence to support the fact that ACL6 is the main player for fatty acyl activation and incorporation in WAP-8294A2 biosynthesis. The results also suggest that the molecular basis for the acyl chain diversity in the WAP-8294A family is the presence of functionally overlapping ACLs.

Source: RSC Advances

DOI: 10.1039/c5ra20784c

Authors: Haotong Chen, Andrew S. Olson, Wei Su, Patrick H. Dussault, Liangcheng Du

Institution: University of Nebraska–Lincoln

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Natural Science Foundation of China, National Institute of Allergy and Infectious Diseases

Awards: Discovering New Anti-Infective Agents from Lysobacter, G5974094165