Work

Catecholamine cardiomyopathy: review and analysis of pathogenetic mechanisms.

Year: 1990

Type: review

Abstract: Catecholamines given in high concentrations produce myocardial damage in several mammalian species. The histological changes are similar to those found in patients given large amounts of pressor agents and in those who develop pheochromocytomas. They include myofiber necrosis, myofibrillar degeneration, and mononuclear leukocytic infiltration. Cardiac function is significantly impaired. Endogenous release of catecholamines can also induce myocardial injury in rabbits infused with tyramine. Anatomic and functional abnormalities described in various models of catecholamine cardiomyopathy are summarized. The several major theories regarding pathogenesis are reviewed. Recent data suggesting that O2-derived free radical generation is involved are discussed.

Source: PubMed

Authors: J P Jiang, S E Downing

Institution: Yale University

Language: English

Topic: Takotsubo Cardiomyopathy and Associated Phenomena

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute

Awards: RELATIONSHIP OF DIABETES TO CATECHOLAMINE CARDIOMYOPATHY, ISCHEMIA AND HYPOXIA IN THE NEONATAL HEART