Association between polygenic risk for schizophrenia, neurocognition and social cognition across development
Year: 2016
Type: article
Study design: Observational Study
Abstract: Breakthroughs in genomics have begun to unravel the genetic architecture of schizophrenia risk, providing methods for quantifying schizophrenia polygenic risk based on common genetic variants. Our objective in the current study was to understand the relationship between schizophrenia genetic risk variants and neurocognitive development in healthy individuals. We first used combined genomic and neurocognitive data from the Philadelphia Neurodevelopmental Cohort (4303 participants ages 8-21 years) to screen 26 neurocognitive phenotypes for their association with schizophrenia polygenic risk. Schizophrenia polygenic risk was estimated for each participant based on summary statistics from the most recent schizophrenia genome-wide association analysis (Psychiatric Genomics Consortium 2014). After correction for multiple comparisons, greater schizophrenia polygenic risk was significantly associated with reduced speed of emotion identification and verbal reasoning. These associations were significant by age 9 years and there was no evidence of interaction between schizophrenia polygenic risk and age on neurocognitive performance. We then looked at the association between schizophrenia polygenic risk and emotion identification speed in the Harvard/MGH Brain Genomics Superstruct Project sample (695 participants ages 18-35 years), where we replicated the association between schizophrenia polygenic risk and emotion identification speed. These analyses provide evidence for a replicable association between polygenic risk for schizophrenia and a specific aspect of social cognition. Our findings indicate that individual differences in genetic risk for schizophrenia are linked with the development of aspects of social cognition and potentially verbal reasoning, and that these associations emerge relatively early in development.
Source: Translational Psychiatry
DOI: 10.1038/tp.2016.147
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,290
Awards: Multimodal brain maturation indices modulating psychopathology and neurocognition, Neurodevelopmental Genomics: Trajectories of Complex Phenotypes, Developmental Trajectories of Negative Symptoms in Schizophrenia, G1483473580, G2013484569, The genomic bridge project (GBP), Neuroimaging genetics to study social cognitive deficits in ASD and schizophrenia, 2/2 Neurodevelopmental Genomics: Trajectories of Complex Phenotypes, Neuroimaging genetics to study social cognitive deficits in ASD and schizophrenia, Schizophrenia genetics, neural and cognitive phenotypes, and social functioning, G76570769, The Future of Genomics Medicine in Patient Care: Contributions from CHOP, A Prospective Study of Endophenotypes in At-Risk Youths and Their Siblings, Dimensional Neurogenetic Markers of Limbic System Integrity & Psychiatric Illness, Research and Mentoring on Integrating Psychiatric Genetics and Neuroscience, 2/4-Psychiatric GWAS Consortium: Genomic Follow-Up Next-Gen Sequencing & Genotypi, G9000025879, G9000088184, G9000295631
OpenAlex ID: W2536245292