Evaluation of activity of triclabendazole against Taenia solium metacestode in naturally infected pigs
Year: 2015
Type: article
Abstract: OBJECTIVE: To assess the efficacy of triclabendazole (TCBZ) in porcine cysticercosis. METHODS: Eighteen naturally infected cysticercosis pigs were divided into 3 groups of 6 individuals each. The first group was treated orally with TCBZ at a single dose of 30 mg/kg of body weight, the second group was treated orally with oxfendazole at a single dose of 30 mg/kg of body weight and the third group received a placebo (control group). All animals were kept under the same management conditions. The pigs were euthanized 17 wk post-treatment and the number of surviving cysts in muscles was assessed and compared between groups. RESULTS: All pigs treated with oxfendazole had only degenerated cysts in their carcasses. In contrast, TCBZ had very little effect against the parasitic cysts. Cysts from pigs in the TCBZ group looked apparently normal after treatment. However, histological evaluation showed a mild to moderate degree of inflammation. CONCLUSIONS: TCBZ is not an efficacious drug against Taenia solium cysticercosis in swine using a single dose.
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: G136699190, Veterinarian Training in Zoonotic Diseases in Developing Countries, G1933198239, G4824069833, G4906319943, Definition and Characterization of the Contribution of Neurocysticercosis to Seizure Burden in Endemic Areas., G5744492008, Training in Infectious Diseases in Peru - Time for Implementation Research
OpenAlex ID: W2199547434