Work

Optimal detection of infratentorial lesions with a combined dual-echo MRI sequence: “PT2”

Year: 2015

Type: article

Abstract: BACKGROUND: The infratentorial compartment is cardinal for multiple sclerosis (MS) diagnosis. T2-weighted (T2) and proton density-weighted (PD) magnetic resonance imaging (MRI) can visualize infratentorial lesions, but only suboptimally. OBJECTIVE: To combine PD and T2 for better lesion assessment. METHODS: T2 and PD from 35 cases were averaged to form "PT2" images. Two raters counted infratentorial lesions and qualitatively assessed their conspicuity. RESULTS: PT2 showed 244 infratentorial lesions, of which 94% and 74% were seen in PD and T2. PT2 received higher grades for image quality and lesion conspicuity (p < 0.001 for all comparisons). CONCLUSION: PT2 could improve our ability to diagnose and monitor MS.

Source: Multiple Sclerosis Journal

DOI: 10.1177/1352458515615226

Authors: María I Gaitán, Paulina Yañes, Pascal Sati, Carlos Romero, Daniel S Reich, Jorge Correale

Institutions: Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia, National Institutes of Health, National Institute of Neurological Disorders and Stroke

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke