Work

The N terminal region of human tau is present in Alzheimer's disease protein A68 and is incorporated into paired helical filaments.

Year: 1991

Type: article

Abstract: Antibody (Ab) E-1 was raised to the amino terminus (19 to 33 amino acid residues) of human tau. It recognized Alzheimer's disease proteins A68 (MW 60, 64, 68 kd), labeled paired helical filaments, and had no reactivity with tau from rat, mouse, and bovine brains. The results indicate that the N terminus of tau is incorporated in A68 proteins and paired helical filaments and that human tau proteins contain species-specific amino acid sequences.

Source: PubMed Central

Authors: A Crowe, H Ksiezak-Reding, W K Liu, D W Dickson, S H Yen

Institutions: Albert Einstein College of Medicine, Yeshiva University

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Aging

Award: AGING AND ALZHEIMER DEMENTIA--ROLE OF FIBROUS PROTEINS