Work

Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer

Year: 2015

Type: article

Abstract: Mutations affecting multiple ribosomal proteins are implicated in cancer. Using genetic mosaics in the fruit fly Drosophila, we describe 3 apoptotic mechanisms that affect Rp/Rp homozygous mutant cells, Rp/+ heterozygous cells, or Rp/+ heterozygous cells in competition with nearby wild type cells, and discuss how apoptosis might be related to cancer predisposition.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2015.1029065

Authors: Nicholas E. Baker, Abhijit Kale

Institution: Albert Einstein College of Medicine

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Research to Prevent Blindness, National Institutes of Health, National Institute of General Medical Sciences