The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology
Year: 2015
Type: review
Abstract: The mitochondrial permeability transition (PT) is a permeability increase of the inner mitochondrial membrane mediated by a channel, the permeability transition pore (PTP). After a brief historical introduction, we cover the key regulatory features of the PTP and provide a critical assessment of putative protein components that have been tested by genetic analysis. The discovery that under conditions of oxidative stress the F-ATP synthases of mammals, yeast, and Drosophila can be turned into Ca(2+)-dependent channels, whose electrophysiological properties match those of the corresponding PTPs, opens new perspectives to the field. We discuss structural and functional features of F-ATP synthases that may provide clues to its transition from an energy-conserving into an energy-dissipating device as well as recent advances on signal transduction to the PTP and on its role in cellular pathophysiology.
Source: Physiological Reviews
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funders: Fondazione Telethon, Ministero dell’Istruzione, dell’Università e della Ricerca, Università degli Studi di Padova, Associazione Italiana per la Ricerca sul Cancro, Università degli Studi di Udine, National Institute on Drug Abuse, National Institute of General Medical Sciences, Office of Extramural Research, National Institutes of Health
OpenAlex ID: W2202366653