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Rat liver contains a potent endogenous inhibitor of inositol 1,3,4,5-tetrakisphosphate 3-phosphatase

Year: 1990

Type: article

Abstract: When Ins(1,3,4,5)P4 was incubated with a rat liver 100,000 g supernatant, about 93% of the substrate was metabolized by a 5-phosphatase, and only 7% by a 3-phosphatase. Ion-exchange chromatography of the supernatant specifically increased its 3-phosphatase activity 72 +/- 3-fold. This activated enzyme was inhibited by a heat-stable factor present in both the soluble and particulate portions of the cell.

Source: Biochemical Journal

DOI: 10.1042/bj2670831

Authors: M E Hodgson, S B Shears

Institutions: National Institutes of Health, National Institute of Environmental Health Sciences

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2202691332

FWCI: 1.283

Cites: 17

Cited by: 15

Related to: 10