Year: 2015
Type: review
Abstract: A revolution in cancer research is underway. Spurred by the advent of the CRISPR-Cas9 technology, new methods to probe the mammalian genomes are being developed. By providing simple, flexible, and cost-effective ways to edit and manipulate the genome of somatic cells of adult animals, these new methods present the opportunity to model cancer progression in vivo with an unprecedented degree of sophistication. Here we provide a brief overview of this exciting and fast-moving field.
Source: Swiss Medical Weekly
Authors: Ram Kannan, Andrea Ventura
Institution: Memorial Sloan Kettering Cancer Center
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
Funder: National Cancer Institute
OpenAlex ID: W2202809274