Work

Induction of potent systemic anti-melanoma immunity through intratumoral CD40 activation and checkpoint blockade

Year: 2015

Type: article

Abstract: Meeting abstracts Agonistic CD40 antibodies generate strong tumor specific CD8 T cell response and anti-tumor activity; however systemic anti-CD40 therapy has been associated with cytokine release syndrome and liver toxicity. We studied the anti-melanoma activity and mechanism of action of a

Source: Journal for ImmunoTherapy of Cancer

DOI: 10.1186/2051-1426-3-s2-p313

Authors: Manisha Singh, Zhimin Dai, Hiep Khong, Christina Vianden, Mark Cantwell, Willem Overwijk

Institution: The University of Texas MD Anderson Cancer Center

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,490