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Reduction of parathyroid hormone with vitamin D supplementation in blacks: a randomized controlled trial

Year: 2015
Type: article
Abstract: BACKGROUND: Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Conflicting reports in Blacks exist on the PTH response to vitamin D to supplementation. METHODS: During 3 winters from 2007-2010, 328 healthy Blacks (median age, 51 years) living in Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. PTH was measured in 254 participants at baseline and at the end of vitamin D supplementation period. RESULTS: The differences in PTH between baseline and 3 months were 3.93 pg/mL for those receiving placebo, -3.37 pg/mL for those receiving 1000 IU/d, -6.76 pg/mL for those receiving 2000 IU/d, and -8.99 pg/mL for those receiving 4000 IU/d ( -2.98 pg/mL for each additional 1000 IU/d of vitamin D3; p<0.001). CONCLUSION: We found a significant decrease in PTH with increasing doses of vitamin D supplementation up to intakes of 4000 IU/d in Blacks. Clinical Trials.gov: NCT00585637.
DOI: 10.1186/s40795-015-0024-8
Authors: Paulette D. Chandler, Foluso Agboola, Kimmie Ng, Jamil B. Scott, Bettina F. Drake, Gary G. Bennett, Andrew T. Chan, Bruce W. Hollis, Karen M. Emmons, Charles S. Fuchs, Edward L. Giovannucci
Institutions: Brigham and Women's Hospital, Harvard University, Dana-Farber Cancer Institute, Michigan State University, Washington University in St. Louis, Duke University, Massachusetts General Hospital, Medical University of South Carolina
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,290
Funders: U.S. Department of Defense, Pharmavite, Harvard University, Harvard Catalyst, National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences, DOD Prostate Cancer Research Program
Awards: Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer, G1460768082, G1470284823, G166012955, G1978278092, G2661966628, Community-based Obesity Prevention among Blacks, G3615943839, G4848865924, G520401124, G6424384527, Mentored Patient-Oriented Research in Digestive Diseases, G7060033699, The VITamin D and OmegA-3 TriaL (VITAL), G9000089438, G9000307188
OpenAlex ID: W2204358078
FWCI:
Cites: 56
Cited by: 3
Related to: 10