A Comparison of the Efficacy and Safety of Intranasal Sufentanil/midazolam and Ketamine/midazolam for Sedation and Analgesia in a Paediatric Population Undergoing Multiple Dental Extractions
Year: 2005
Type: dissertation
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: This study was designed to evaluate the efficacy and safety of intranasal sufentanil/midazolam [S/M] and ketamine/madazolam [K/M] for sedation and analgesia in preschool children that require dental surgery [extractions].Fifty children [ASA 1] aged 5 -7 years, requiring six or more dental extractions under general anaesthesia, were allocated to two groups of 25 children to receive either ketamine 5 mg/kg or sufentanil 20µg intranasally, 20 minutes before induction of surgery in this randomised double-blind study.All the children in both groups in addition concurrently received nasal midazolam 0,3 mg/kg.For induction of anaesthesia, sevoflurane in nitrous oxide and oxygen, was used.S/M was accepted significantly better as a nasal pre-medication [p<0.05].Both groups were equally sedated and a smooth mask induction of anaesthesia was experienced in the majority of children.Recovery of children in both groups were similar; 82% of the S/M group were fully recovered 120 minutes post-operatively versus 80% in the K/M group [p>0,05].Effective postoperative analgesia for multiple extractions was provided.For pain evaluation, children were divided into two groups, a nonresponder group where all pain values over time were more than 40 and a responder group where pain values were equal to, or less than 40.Seventy two percent of children in the S/M group were responders as to fifty two percent in the K/M group [p>0,05].No adverse respiratory, cardiovascular or other effects were recorded.This study showed that intranasal administration of sufentanil /midazolam or ketamine/midazolam, provides safe and effective sedation and analgesia in children aged 5-7 years undergoing multiple dental extractions.
Authors: De La Harpe, Charl Jacques
Language: English
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2204621836