Work

Tumor suppressor genes as negative growth regulators in development and differentiation

Year: 1995

Type: article

Abstract: Tumor suppressor genes have received much attention for their roles in the development of human malignancies. However, their gene products (proteins) function as negative growth regulators and are highly expressed in many tissues during embryonic development, suggesting that they might function as critical proteins in differentiation and development. The evidence implicating tumor suppressor proteins in cellular differentiation and embryonic development will be presented with special attention to the neurofibromatosis 1, neurofibromatosis 2, and tuberous sclerosis 2 gene products.

Source: The International Journal of Developmental Biology

DOI: 10.1387/ijdb.8901192

Author: D H Gutmann

Institution: Washington University in St. Louis

Language: English

Topic: Neurofibromatosis and Schwannoma Cases

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: James S. McDonnell Foundation, Muscular Dystrophy Association, National Institutes of Health