Year: 2006
Type: article
Abstract: The present study was carried out to evaluate the antimicrobial and\nantioxidant activities of methanol extract of Careya arborea (MECA)\nstem barks (Myrtaceae) in various in-vitro systems. Antimicrobial\nactivities of MECA were carried out using disc diffusion methods with\nGram positive and Gram negative bacteria and some fungal species. MECA\nshowed broad-spectrum antimicrobial activity against all tested\nmicroorganisms. Antioxidant and free radical scavenging activities of\nMECA was assessed by using 1,1-diphenyl-2-picryl-hydrazyl radical\n(DPPH), superoxide anion radical, nitric oxide radical and hydroxyl\nradical scavenging assays. The antioxidant activity of MECA increased\nin a concentration dependent manner. In DPPH radical scavenging assay\nthe IC50 value of the extract was found to be 132.25 mg/mL. MECA was\nfound to inhibit the nitric oxide radicals generated from sodium\nnitroprusside. The IC50 value was found to be 72.54 mg/mL, whereas the\nIC50 value of curcumin was 20.4 mg/mL. Moreover, the MECAwas found to\nscavenge the superoxide generated by phenazine methosulphate (PMS) /\nnicotinamide adenine dinucleotide (NADH)-nitroblue tetrazolium (NBT)\nsystem. MECA was also found to inhibit the hydroxyl radical generated\nby Fenton’s reaction, where the IC50 value of MECA was found to\nbe more than 1000 mg/mL and for catechin the IC50 value was found to be\n5 mg/mL. The results obtained in the present study indicate that the\nMECA can be a potential source of natural antimicrobial and antioxidant\nagents.
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2208475655