The immune response in paediatric cancer
Year: 2010
Type: article
Abstract: : Recent years have seen something of a resurgence of interest in the role of the immune system in the initiation, development, control and treatment of human cancers. Growing evidence indicates a complex set of interactions between developing tumours and the host immune system. In this review, we examine the major types of tumour-infiltrating immune cells and discuss their significance in terms of both pro- and anti-tumour effects. In the second part of the review, we consider a number of the potential immune escape mechanisms which may be employed by tumours, including intrinsic signalling pathways such as STAT3 and NF-B; cytokines such as TGF-; metabolic pathways including indoleamine 2,3-dioxygenase (IDO) and loss of expression or shedding of immune mediators such as MHC class I and NKG2D. Although much of the literature in this field relates to adult malignancies, we focus in this review on paediatric cancers and discuss potential differences in the role of the immune system in these malignancies, compared to adult-type cancers.
Authors: Daniel A. Morgenstern, John Anderson
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2208624760