Work

The Immunology of Bipolar Disorder

Year: 2014

Type: review

Abstract: Bipolar disorder (BD) is a psychiatric condition associated with elevated frequency of clinical comorbidities and cognitive impairment. The neurobiology of BD is not completely understood. Recent evidence has implicated immune dysfunction in its physiopathology. Here, we review several data supporting the presence of immunological dysfunction in BD: (i) increased frequency of autoimmune diseases; (ii) distinct immune cell profile; (iii) release of/altered cytokines by stimulated mononuclear cells; (iv) elevated levels of circulating immune markers, and (v) inflammatory changes in the central nervous system. We also discuss the interplay between immunological dysfunction and neuroprogression in BD.

Source: NeuroImmunoModulation

DOI: 10.1159/000356539

Authors: Izabela Guimarães Barbosa, Rodrigo Machado-Vieira, Jair C. Soares, Antonio L. Teixeira

Institutions: Universidade Federal de Minas Gerais, National Institutes of Health, Universidade de São Paulo, National Institute of Mental Health, The University of Texas Health Science Center at Houston

Language: English

Topic: Bipolar Disorder and Treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado de Minas Gerais, National Institutes of Health