Year: 2008
Type: article
Abstract: This dissertation examined the effect of different exercise-induced blood flow patterns on endothelial function in humans.Young and older subjects performed dynamic muscle contractions to modulate blood flow patterns during exercise.Conduit artery mean blood flow was measured during exercise using ultrasound Doppler.Antegrade blood flow, retrograde blood flow, and shear stress were computed.Endothelial-dependent vasodilation was assessed by measuring brachial artery flow-mediated vasodilation (FMD) and peak reactive hyperemia using ultrasound Doppler and venous strain-gauge plethysmography, respectively.Venous blood samples were collected by venipuncture and analyzed for plasma levels of von Willebrand Factor (vWF), protein carbonyls, and thiobarbituric acid reactive substances (TBARS).Shear stress showed a negative curvilinear relationship with vascular resistance during exercise.Retrograde blood flow was positively correlated with shear stress and negatively correlated with vascular resistance during exercise.The incorporation of Thistlethwaite and Benjamin C. Thompson for their technical assistance during the data collection and analysis stages of this dissertation.Third, I would like to acknowledge the Department of Kinesiology at The University
Author: Joaquin U. Gonzales
Institution: University of Toledo
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: University of Toledo
OpenAlex ID: W2209453455