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The Nodes of Ranvier: Molecular Assembly and Maintenance

Year: 2015
Type: preprint
Abstract: Action potential (AP) propagation in myelinated nerves requires clustered voltage gated sodium and potassium channels. These channels must be specifically localized to nodes of Ranvier where the AP is regenerated. Several mechanisms have evolved to facilitate and ensure the correct assembly and stabilization of these essential axonal domains. This review highlights the current understanding of the axon intrinsic and glial extrinsic mechanisms that control the formation and maintenance of the nodes of Ranvier in both the peripheral nervous system (PNS) and central nervous system (CNS).
DOI: 10.1101/cshperspect.a020495
Language: English
Open Access status: bronze
Funders: National Multiple Sclerosis Society, Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, E-Rare, Multiple Sclerosis Society, Israel Science Foundation, National Institutes of Health, National Institute of Neurological Disorders and Stroke
Awards: G1871880350, Mechanisms of CNS node of Ranvier formation., Role of axoglial CAMs in the organization of myelinated axons, Neuroglial interactions at nodes of Ranvier, Neuroglial interactions at the node of Ranvier, G9000128193
OpenAlex ID: W2209818202
Cites: 116
Cited by: 189
Related to: 10